Small molecule modulators for CRAC channel
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Use iPS cells technology to investigate ion channelopathies
The long-term goal in this endeavor is to create human models of cardiovascular and neurological channelopathies by generating iPS cell-derived cardiac or neuronal cells from fibroblasts from patients, to establish pharmacology profiles of known drugs used to treat each model, as well as to uncover drugs that may be of therapeutic value in treating these disorders. These cells also have the potential to be used in regenerative therapy, to restore function to damaged or failing organs without fear of autoimmune rejection. At the initial stage, we will focus on patients with Brugada syndrome, a genetic disease that is characterized by abnormal electrocardiogram (ECG) recordings with typical ST segment elevation in the anterior precordial leads V1-V3 and an increased risk of sudden death due to ventricular fibrillation in heart.