"What I cannot create, I do not understand."                    — Richard Feynman


October 3, 2017

Congratulations to Nhung Nguyen as a co-author for a paper accepted by BMC Bioinformatics, entitled: "Integrated pipeline for inferring the evolutionary history of a gene family embedded in the species tree: a case study on the STIMATE gene family"!

September 26, 2017

Congratulations to Lian He for winning the Robert and Anabel Bruce Travel Award to attend a conference

September 26, 2017

Congratulations to Ji Jing for winning an ASCB Travel Award to attend the 2017 ASCB/EMBO meeting at Philadelphia! 

September 14, 2017

Congratulations to Guolin Ma for acceptance of a manuscript, entitled "The STIM-Orai pathways: Light-Operated Ca2+ Entry Through Engineered CRAC Channels", by Advances in Experimental Medicine and Biology.

September 6, 2017


Photonics MEDIA

September 6, 2017 | College Station

"Optogenetics Controls Interorganellar Communication at Nanoscale"

August 26, 2017


Asian Scientist Magazine

September 6, 2017  | IN THE LAB

"Using Light To Build Bridges In Cells"

August 16, 2017

The Zhou Lab has been awarded a High-Impact / High-Risk Research Award by the Cancer Prevention and Research Institute of Texas (CPRIT) to develop novel tools and interventional approaches to combat cancer. 

August 14, 2017

Breaking News


August 14, 2017 | Nicholas Miliaras

"Building an Optogenetic Bridge Between Membranes"

August 4, 2017

Sina News 



Sohu News



August 3, 2017

Congratulations to Ji Jing for winning a Poster Award at the Gordon Research Conference in Organellar channels and transporters!

July 26, 2017


Vital Record

July 24, 2017 | Christina Sumners

July 24, 2017

An article by Lian He and Ji Jing were highlighted as cover story by Chemical Science!

July 12, 2017

An article entitled "Targeted DNA methylation in vivo using an engineered dCas9-MQ1 fusion protein" was published online by Nature Communications!  (collaboration with Dr. Margret Goodell at BCM)

July 10, 2017

An article entitled "Mutations in 5-methylcytosine oxidase TET2 and RhoA cooperatively disrupt T cell homeostasis" was published online by Journal of Clinical Investigation! (Collaboration with Dr. Yun Huang at Texas A&M)

July 09, 2017

Congratulations to Tianyu Jiang for acceptance of a manuscript, entitled "New bioluminescent coelenterazine derivatives with various C-6 substitutions", by Organic & Biomolecular Chemistry!

June 08, 2017

Congratulations to Lian He and Qian Zhang for a manuscript, entitled "Optogenetic approaches to control calcium entry in non-excitable cells", published in the book Calcium Entry Channels in Non-Excitable Cells by CRC Press.

 June 7, 2017

Congratulations to Lian He and Ji Jing for acceptance of a research article by Chemical Science, entitled "Optical Control of Membrane Tethering and Interorganellar Communication at Nanoscales"!

May 26, 2017

Congratulations to Lian He and Ji Jing for winning the 2017 travel awards in recognition of their excellent research achievements!

May 8, 2017

The Texas A&M University System Board of Regents has officially approved Dr. Yubin Zhou's early promotion to the rank of Associate Professor with Tenure after four-and-half years' service at TAMU-IBT.  

April 28, 2017

Congratulations to Ji Jing and Minjung Lee for winning the Outstanding Graduate Research Award at the 31th SCBA annual meeting!

April 20, 2017


Vital Record

April 20, 2017 | Christina Sumners

"Epigenetic changes on demand: turning the 'traffic lights' of DNA from red to green"

April 19, 2017

JACS Spotlights 

Apr 19, 2017 | Deirdre Lockwood

"Epigenetic changes on demand with an enzyme-small molecule combo"

April 19, 2017

An article entitled "Discovery of the first environment-sensitive fluorescent probe for GPR120 (FFA4) imaging" was published online at ACS Medicinal Chemistry Letters! (collaboration with Dr. Minyong Li at SDU)

April 5, 2017

An article entitled "cybLuc: An Effective Aminoluciferin Derivative for Deep Bioluminescence Imaging" was published online at Analytical Chemistry! (collaboration with Dr. Minyong Li at SDU)

March 15, 2017

Congratulations to Yi Liang and Guolin Ma for acceptance of a paper, entitled "Engineered split-TET2 enzyme for inducible epigenetic remodeling", by Journal of the American Chemical Society ! 

  • Highlighted in ACS Editors' Choice (based on the recommendations from over 400 editors of ACS' 40+ premier journals).

March 3, 2017

Congratulations to Lian He and Peng Tan for publication of a paper in the March issue of  Trends in Biotechnology, entitled "Optogenetic immunomodulation: shedding light on antitumor immunity"!

February 1, 2017

Congratulations to Guolin Ma, Yuepeng Ke and Lian He for acceptance of an article by Current Molecular Medicine, entitled "Molecular determinants for STIM1 activation during store-operated Ca2+ entry"! Highlighted in Editor's Choice!

January 18, 2017

Dr. Yubin Zhou was invited to join the Editorial Board of Scientific Reports.

January 12, 2017

Congratulations to Guolin Ma as a co-author for a research article accepted by Nature Cell Biology, entitled "The LINK-A lncRNA interacts with PI(3,4,5)P3 to hyperactivate AKT and confer resistance to AKT inhibitors"!

January 10, 2017

Congratulations to Guolin Ma, Kevin Wen and Lian He for acceptance of a review by Cell Calcium, entitled "Optogenetic toolkit for precise control of calcium signaling"!

January 1, 2017

Dr. Yubin Zhou was appointed to the Editorial Board of Molecular and Cellular Biology.

2016 NEWS

November 21, 2016

Congratulations to Ji Jing for winning a Travel Award from the Graduate & Professional Student Council at Texas A&M University! 

At the 2016 Institute of Biosciences and Technology (IBT) Trailblazers Luncheon honoring Dr. Arthur Laganowsky, recipient of an NIH Directors New Innovator Award, Dr. Yun (Nancy) Huang, recipient of CPRIT Emerging Investigator Award, and Dr. Yubin Zhou, American Cancer Society Research Scholar Award, pictured with Dr. Carrie Byington, Vice Chancellor for Health Services, Dean of the College of Medicine and Sr. VP for the Health Science Center at Texas A&M University. Congratulations to the trailblazers taking medicine from the field to the clinic! #BeFearless

November 3, 2016

Congratulations to Zhenzhen Liu for an article published in ChemBioChem entitled "TET1-mediated Oxidation of 5-formylcytosine (5fC) to 5-carboxycytosine (5caC) in RNA"!

October 10, 2016

The Zhou Lab received a Research Scholar Grant from the American Cancer Society to develop novel anti-cancer therapies by targeting aberrant calcium signaling. 

September 14, 2016

Congratulations to Lian He and Peng Tan as co-authors for an article accepted by Molecular Cell, entitled "TRIM14 inhibits cGAS degradation mediated by selective autophagy receptor p62 to promote innate immune response"!

September 12, 2016

Congratulations to Lian He and Guolin Ma as co-authors for a paper accepted by Pluger Arhiv - European Journal of Physiology, entitled "Molecular mechanisms underlying inhibition of STIM1-Orai1 mediated Ca2+ entry induced by 2-aminoethoxydiphenyl borate"!

May 6, 2016

Congratulations to Lian He for winning the 2nd Prize of Poster Award 

at Gulf Coast Consortia (GCC) Symposium on Membrane Biophysics

May 5, 2016

Dr. Yubin Zhou joined the Editorial Board of Current Molecular Medicine as an Associate Editor. A brief biography "Meet Our Associate Editor" can be found here.

May 4, 2016

An article from Zhou and Li labs entitled "Store-operated CRAC channel inhibitors: opportunities and challenges" was published online at Future Medicinal Chemistry.


April 12, 2016

An article from Zhou and Han labs entitled "Illuminating cell signaling with near-infrared light responsive nanomaterialswas published online at ACS Nano

April 7, 2016

The Zhou Lab received a research grant from The Welch Foundation, one of the largest private funding sources for basic chemical research, to devise novel tools to manipulate cellular signaling! 

March 16, 2016



Mar 16, 2016 | Kristen Cowart

"Breaking: doctors can now use light to fight cancer!"

February 24, 2016

ALN Magazine
Feb 22, 2016 | Elizabeth Doughman

February 24, 2016

Feb 24, 2016 | Charles Moore

February 10, 2016      


The Battalion

Featured Stories 

Feb 10, 2016 | Zach Grinovich

"Researchers develop new cancer treatment"

February 10, 2016



Feb 10, 2016 | Justin Cowart

"A new study shows that light can help fight cancer"

February 9, 2016


Optics & Photonics News | The Optical Society

Feb 9, 2016 | Sarah Michaud

"Light activated immune response"

February 7, 2016


Care Homes Today 

Feb 7, 2016 | Georgima Coronil

"New techniques to fight cancer using the power of light"

February 5, 2016


Specialty Pharmacy Times

Feb 5, 2016 | Lauren Santye

"Near infrared laser may enhance cancer immunotherapy"

January 28, 2016

A research article entitled "Discovery of the first environment-sensitive near-infrared (NIR) fluorogenic ligand for a1-adrenergic receptors imaging in vivo" was published at Journal of Medicinal Chemistry.  

January 27, 2016

Jan 27, 2016 | Kara Marker

January 21, 2016


Vital Record 

Jan 21, 2016 | Christina Sumners

"Harnessing the power of light to fight cancer"

January 21, 2016


Australia Network News


"Using light to fight cancer"

January 20, 2016

A research article entitled "Quenching the firefly bioluminescence by various ions" was published at Photochemical & Photobiological Sciences.

January 11, 2016

Congratulations to Guolin Ma as a co-author for a paper accepted by Nature Cell Biology, entitled "The LINK-A lncRNA Activates Normoxic HIF1α Signaling in Triple-negative Breast Cancer"! 

January 5, 2016

A research article entitled "A novel environment-sensitive fluorescent probe for the human Ether-a-go-go-related gene potassium channel" by Zhenzhen Liu et al was published at Analytical Chemistry


December 8, 2015

Congratulations to Lian He, Guolin Ma and Peng Tan for an article published by eLife, entitled "Near-infrared photoactivatable control of Ca2+ signaling and optogenetic immunomodulation"! 

December 7, 2015

Congratulations to Ji Jing as a co-author for a paper published by PNAS, entitled "TMEM110 regulates the maintenance and remodelling of mammalian ER-plasma membrane junctions competent for STIM–ORAI signaling"! 

November 16, 2015

Qian Zhang joined the Zhou Lab as a visiting scholar --- Welcome!!!

October  16, 2015 

Congratulations to Zhenzhen Liu for acceptance of an article by Analyst !

September 30, 2015 

Congratulations to Ji Jing & Lian He for an article published at Nature Cell Biology, entitled "Proteomic mapping of ER-PM junctions identifies STIMATE as a regulator of Ca2+ influx"(doi: 10.1038/ncb3234).

Featured as "News and Views" by Nature Cell Biology: "STIMATE reveals a STIM1 transitional state"  

Wikipedia links for TMEM110 and LiMETER (optical control of ER-PM membrane contact sites).  

September 12, 2015  

A review entitled "SOCE and cancer: recent progress and new perspectives" was accepted by International Journal of Cancer. 


July 22, 2015 

An online protocol describing "Proteomic mapping of ER-PM junctions in living HEK293 cells" by Lian He et al. was available at Nature Protocol Exchange.


June 16, 2015 

Congratulations to Dr. Guolin Ma & Lian He for the acceptance of a research article by Nature Communicationsentitled "Inside-out calcium signaling prompted by STIM1 conformational switch".

Videos associated with this article is available at Youtube 


May 20, 2015

Congratulations to Ji Jing for winning the 3rd Prize for outstanding performance and excellence in oral scientific presentation at the 29th SCBA-Texas Annual Symposium!


March 3, 2015 

A research article entitled "Fluorogenic probe for the human Ether-a-go-go-related gene potassium channel imaging" by Zhenzhen Liu et al was published at Analytical Chemistry


January, 2015

Zhenzhen Liu and Dr. Hongli Li joined the Zhou Lab as visiting scholars --- Welcome!!!

A research article entitled "Discovery of a series of 2-phenylnaphthalenes as firefly luciferase inhibitors" was published online at RSC Advances.


October 09, 2014

An article entitled "STIM1 triggers a gating rearrangement at the extracellular mouth of the ORAI1 channel." was published online by Nature Communications2014,5:5164. (PMID:25296861).


August 1, 2014

The Zhou Lab received an  RO1 grant from National Institutes of Health to study the molecular controlling mechanisms of ER-PM junctions in mammalian cells.  


July 31, 2014 

IBT Imaging Workshop by the joint IBT-Baylor Center for Advanced Imaging

Featuring high-content imaing and analysis, 3D imaing, TIRF microscopy, mRNA FISH and spectral imaging with NIKON confocal setup.

Location: Rm 1119

12:00 am -1:00 pm,  July 31, 2014

Free food and drinks provided  


March 14, 2014 

IBT Technology Forum:

CRISPR/CAS9 as a versatile platform for genome editing and engineering

 Location: Rm 1119

12:00 am -1:00 pm,  March 14, 2014 


February 4, 2014 

Welcome Can Li for joining the Zhou Lab as a rotation student!


November 21, 2013 

IBT-BCM Center for Advanced Imaging Workshop

 Location: Rm 1119

12:00 am -1:00 pm,  December 20, 2013


November 9, 2013 

Welcome Shin Hanna for joining the lab as a rotation student!


July 14, 2013 

An article entitled "Initial activation of STIM1, the regulator of store-operated calcium entry" by Zhou Y et al. was published online (doi:10.1038/nsmb.2625) by Nature Structural & Molecular Biology. 2013,20:973-981.

Highlighted in NSMB "NEWS AND VIEWS"

conformational dynamics of STIM1 activation


June 3, 2013 

A book chapter entitled "STIM-ORAI interactions that control the CRAC channel" by Gudlur A, Zhou Y and Hogan PG was published online by Current Topics in Membranes[PMID: 23890110] 


May 10, 2013 

Congratulations to Lian He, M.S., for winning the poster award at the 2013 Annual IBT Research Symposium! 


March 13, 2013

 An article by Zhou Y et al. was published online and showcased as back cover of Metallomics issue 1, 2013 (see comments in Metallomics Blog). Calciomics: integrative studies on Ca2+ binding proteins and their interactomes in biological systems. [PMID: 23235533] 

Highlighted as the "Top Ten most accessed articles" in January.


January 31, 2013 

Nikon fluorescence microscope on-site training

Location: Suite 909

10:00 am -12:00 pm, January 31 Thursday 2013


January 9, 2013

A book chapter entitled "Probing Ca2+ binding capability of viral proteins with the EF-hand motif by grafting approach" for Methods in Molecular Biology by Zhou Y et al. was published online.