"What I cannot create, I do not understand." — Richard Feynman
October 28, 2020
A 5-year study led by Dr. Lian He, entitled "Engineering of a bona fide light-operated calcium channel" was accepted by Nature Communications! Our third NC series in a row for 2020!
LOCA: a Light-Operated Calcium Channel engineered from ORAI1, enabling optical control of calcium signals, suppression of aberrant stem cell differentiation, and remote interrogation of neurodegenerative diseases!
October 17, 2020
A collaborative paper with the Huang Lab @TAMU-IBT, entitled "Reliable tumor detection by whole-genome methylation sequencing of cell-free DNA in cerebrospinal fluid of pediatric medulloblastoma", was published online with Science Advances.
October 15, 2020
A collaborative study led by Ji Jing and Zhao Zhang, entitled "Characterization of the dual functional effects of heat shock proteins (HSPs) in cancer hallmarks to aid development of HSP inhibitors", was accepted by Genome Medicine.
October 7, 2020
A manuscript by Drs. Tianlu Wang, Lian He, and Guolin Ma, entitled "Caffeine-operated synthetic modules for chemogenetic control of protein activities by life style", was accepted by Advanced Science.
COSMO: A novel chemical biology tool to control protein activity with caffeine. A cup of tea, energy drink or Soda will do the trick!
August 27, 2020
A manuscript by Rui Chen, and Dr. Ji Jing, entitled "Intelligent cell-based therapies for cancer and autoimmune disorders", was accepted by Current Opinion in Biotechnology!
A comprehensive overview on CAR-based intelligent cell therapies against cancer and immune disorders.
June 20, 2020
A manuscript by Nhung Nguyen and Dr. Ji Jing, entitled "Optogenetic approaches to control calcium-modulated physiological processes", was accepted by Current Opinion in Physiology.
An informative review on the latest optogenetic tools - Genetically-Encoded Calcium Actuators or Modulators (GECAs) to manipulate calcium signaling and calcium-modulated physiological processes.
June 20, 2020
Our recent photopharmacological tool, piCRAC, was highlighted by JACS as a cover story for the July issue. Now we have a full collection of cover articles with three major chemistry flagship journals, JACS, Angewandte Chemie International Edition, and Chemical Science!
April 30, 2020
Two recent papers were ranked as "Top downloaded paper 2018~2019" - among the most read in their journals!
April 24, 2020
A manuscript by Dr. Guolin Ma et al, entitled "Optical control of CRAC channels using photoswitchable azopyrazoles", was accepted by JACS.
We describe herein a series of synthetic piCRAC compounds to suppress aberrant CRAC channel activity using light. piCRAC displayed promising therapeutic efficacy in a zebrafish model of Stormorken syndrome to alleviate bleeding and thrombocytopenia!
March 31, 2020
A manuscript by Yi-Tsang Lee and Lian He, entitled "Expanding the chemogenetic toolbox by circular permutation", was accepted by Journal of Molecular Biology.
A collaborative paper, entitled "A combination strategy targeting enhancer plasticity exerts synergistic lethality against BETi resistant leukemia cells", was accepted by Nature Communications.
ZHOU LAB | 2019 NEWS
ZHOU LAB | 2019 NEWS
Congratulations to Nhung Nguyen for winning an NSF-sponsored award by the Society for Biological Engineering to present her latest work on optogenetic immunotherapy in the 2019 Optogenetic Technologies and Applications Conference at Boston!
Congratulations to Nhung Nguyen for wining a highly competitive Outstanding Poster Presentation Award at the 2019 NCI Alliance for Cancer Nanotechnology Meeting @NIH!
A collaborative paper, entitled "Antibiotic treatment ameliorates Ten-eleven Translocation 2 (TET2) loss-of-function associated hematological malignancies" was published online with Cancer Letters. Check out how antibiotics can benefit lymphoma and leukemia treatment.
New collaborative work with Nancy Huang Lab @ TAMU, entitled "Tet inactivation disrupts YY1 binding and long-range chromatin interactions during embryonic heart development", was published online at Nature Communications ! See how Tet2/3 ablation leads to the striking ventricular non-compaction cardiomyopathy.
A collaborative paper with Dr. Han Xiao @ Rice U, entitled "Single-Atom Fluorescence Switch: A General Approach towards Visible Light-Activated Dyes for Biological Imaging", was published online at JACS.
A collaborative paper, entitled "Comprehensive characterization of circular RNAs in ~ 1000 human cancer cell lines", was published online with Genome Medicine. A a user-friendly data portal, CircRNAs in cancer cell lines (CircRiC, https://hanlab.uth.edu/cRic) developed by Dr. Leng Han at UT Health.
A collaborative project with Dr. Fen Wang at IBT to develop optogenetic tools for studying metabolic synergy in tumor microenvironment was funded by Cancer Prevention and Research Institute of Texas!
Congratulations to Ji Jing for winning a Postdoctoral Scholar Travel Award from the Texas A&M University Postdoctoral Association, and being invited to give a talk at a Gordon Research Conference, held at West Dover, VT!
Congratulations to Kaycee Nguyen for winning the poster award at the 2019 TAMU IBT Summer Student Research Day under the mentorship of Nhung!
Congratulations to Nhung Nguyen for winning the 2019 IBT Graduate Program Travel Award to attend a FASEB scientific conference!
Congratulations to Nhung Nguyen for winning the 2nd Place Award of Outstanding Achievements in Medical Sciences at the 2019 Annual Graduate Student Research Symposium!
A collaborative study, entitled "Tmem178
negatively regulates store-operated calcium entry in myeloid cells via
association with STIM1" was accepted by Journal of Autoimmunity. (collaboration with Dr. Roberta Faccio at Washington University)
A fruitful year to begin with for the Zhou Lab! Four new grants awarded by NIGMS, NCI, DoD and the Welch Foundation!
Our story of YZ129 as an anti-glioblastoma drug candidate is highlighted as a cover article in the March issue of Cell Chemical Biology!
Our TRIM59-PDCD10 story is highlighted as "Editor's Picks' in cancer cell biology by PLOS collections!
A commentary by Lian He and Peng Tan, entitled "TRIM59 deficiency curtails breast cancer metastasis through SQSTM1-selective autophagic degradation of PDCD10", is published online with Autophagy.
An article published by Advanced Healthcare Materials, entitled "Near‐Infrared‐Light Activatable Nanoparticles for Deep‐Tissue‐Penetrating Wireless Optogenetics", highlighting the features of wireless optogenetics.
An article published by Cell Chemical Biology, entitled "Discovery of small molecule inhibitors of the HSP90-calcineurin-NFAT pathway against glioblastoma"! Congratulations to Zhenzhen, Hongli and Lian!
ZHOU LAB | 2018 NEWS
November 14, 2018
A research article entitled "Calcium oscillations coordinate feather mesenchymal cell movement by SHH dependent modulation of gap junction networks", with Drs. Lian He and Peng Tan as a co-author, was accepted by Nature Communications! (collaboration with Dr. Ang Li & Prof. Chuong Cheng-Ming at USC)
November 7, 2018
The ZHOU Lab has been awarded a 2018 John S. Dunn Foundation Collaborative Research Award to devise chemical biology tools for studying epigenetics (collaboration with Dr. Han Xiao at Rice University).
November 2, 2018
A manuscript entitled "p53-dependent autophagic degradation of TET2 modulates cancer
therapeutic resistance" was published online at Oncogene. Congratulations to Drs. Jixiang Zhang and Lei Guo!
October 23, 2018
A SECOND manuscript accepted by PLOS Biology, entitled "TRIM59 promotes breast cancer motility by suppressing p62-selective autophagic degradation of PDCD10"! Congratulations to Peng, Lian, Ji, and Guolin!
October 1, 2018
A manuscript by Drs. Guolin Ma and Lian He as co-first authors, entitled "Identification of molecular determinants that govern distinct STIM2 activation dynamics", was accepted by PLOS Biology!
September 25, 2018
A research article entitled "STIM2 interacts with AMPK and regulates calcium-induced AMPK activation", with Dr. Ji Jing as a co-author, was accepted by FASEB Journal! (collaboration with Dr. Boyi Gan at MDACC)
September 13, 2018
A research article entitled "LncRNA CamK-A Regulates Ca2+-Signaling-Mediated Tumor Microenvironment Remodeling", with Dr. Guolin Ma as a co-author, was accepted by Molecular Cell! (collaboration with Dr. Aifu Lin at ZJU)
September 1, 2018
The Zhou Lab received an equipment grant from the National Institutes of Health to upgrade a super-resolution fluorescence microscope.
July 19, 2018
Dr. Guolin Ma received the Short Talk Award at the 2018 FASEB conference on Calcium and Cell Function!
June 19, 2018
Nhung Nguyen won the IBT Travel Award to attend a national scientific conference!
June 18, 2018
Dr. Lian He won the Best Poster Award at the FASEB meeting "Calcium and Cell Function: from mechanism to disease" !
May 25, 2018
Guolin Ma and Qian Zhang published a highlighted paper at Chemical Science, entitled "Genetically-encoded tags for real time dissection of protein assembly in living cells"!
Highlighted in Theme Collection: "2018 Chem Sci HOT Article Collections! & "Chem Sci Picks"
May 19, 2018
Congratulations to Dr. Lian He and Dr. Ji Jing!!! Well deserved!
May 18, 2018
Nhung Nguyen won the Outstanding Achievement in Medical Sciences - 1st Place Award for Oral Presentation!
May 18, 2018
Ji Jing won the highly competitive Graduate Research Excellence Award across the College of Medicine at Texas A&M University!
May 12, 2018
Dr. Guolin Ma won the Outstanding Research Award in the 2018 Annual Symposium of SCBA-TX!
April 28, 2018
Big congratulations to Lian He for winning the competitive and prestigious Award for Oustanding Self-Financed Students Abroad by China Scholarship Council!
April 12, 2018
Dr. Guolin Ma, Yuepeng Ke, and Xin Liu published a research article at Angewandte Chemie (highlighted on Cover), entitled "Optogenetic control of voltage gated calcium channels"!
April 2, 2018
The Huang/Zhou labs received a new four-year grant from the American Cancer Society to study the pro-oncogenic role of Bcl6 in blood cancer.
March 22, 2018
The Zhou lab received a 2-year T3 Triad for Transformation Award from The Texas A&M President's Excellent Fund to collaborate with Dr. Fen Wang at IBT-COM and Dr. Yongbo Lu at College of Dentistry to develop optogenetic tools to interrogate metabolism synergy.
February 15, 2018
The Zhou Lab was awarded an Exploratory Research for Technology Development grant by NIGMS to devise innovative tools to probe calcium signaling in the brain and heart.
February 15, 2018
The Huang/Zhou Labs were awarded a five-year RO1 grant by the National Heart, Lung and Blood Institute to study epigenetic control of cardiac development.
February 2, 2018
The Huang/Zhou labs received a Pilot Grant from the Texas Medical Center Digestive Disease Center to study epigenetic mechanisms underlying inflammatory bowel disease.
January 21, 2018
Jia Li published a manuscript at Nucleic Acid Research, entitled "Decoding the dynamic DNA methylation and hydroxymethylation landscapes in endodermal lineage intermediates during pancreatic differentiation of hESC"!
January 10, 2018
Drs. Rod Pettigrew (NAE) and Carrie Byington (NAM) Celebrating @TAMUmedicine proteges Farida Sohrabji and Yubin Zhou at #TAMEST 2018 at @NASA_Johnson, a great event featuring over two dozens NAE/NAS/NAM members and their progeges within Texas!
ZHOU LAB | 2017 NEWS
December 18, 2017
Minjung Lee published a paper at Journal of Visualized Experiments, entitled "An Engineered Split-TET2 Enzyme for Chemical-inducible DNA Hydroxymethylation and Epigenetic Remodeling"!
December 15, 2017
Congratulations to Shufan (Kevin) Wen, a summer intern from Debakey High School, for his early admission by Duke University!
November 30, 2017
The Zhou Lab received the 2017 Excellence in Research Award with a COM medallion, a competitive and prestigious honor awarded by the Texas A&M University College of Medicine to recognize, encourage and reward those individuals whose research efforts have been particularly successful and outstanding and are so widely recognized.
October 3, 2017
Congratulations to Nhung Nguyen as a co-author for a paper accepted by BMC Bioinformatics, entitled: "Integrated pipeline for inferring the evolutionary history of a gene family embedded in the species tree: a case study on the STIMATE gene family"!
September 26, 2017
Lian He won the Robert and Anabel Bruce Travel Award to attend a conference!
September 26, 2017
Ji Jing won an ASCB Travel Award to attend the 2017 ASCB/EMBO meeting at Philadelphia!
September 14, 2017
Dr. Guolin Ma published a book chapter, entitled "The STIM-Orai pathways: Light-Operated Ca2+ Entry Through Engineered CRAC Channels", at Advances in Experimental Medicine and Biology.
August 16, 2017
The Zhou Lab has been awarded a High-Impact / High-Risk Research Award by the Cancer Prevention and Research Institute of Texas (CPRIT) to develop novel tools and interventional approaches to combat cancer.
August 3, 2017
Ji Jing won a Poster Award at the Gordon Research Conference in Organellar channels and transporters!
July 12, 2017
An article entitled "Targeted DNA methylation in vivo using an engineered dCas9-MQ1 fusion protein" was published online by Nature Communications! (collaboration with Dr. Margret Goodell at BCM)
July 10, 2017
An article entitled "Mutations in 5-methylcytosine oxidase TET2 and RhoA cooperatively disrupt T cell homeostasis" was published online by Journal of Clinical Investigation! (Collaboration with Dr. Yun Huang at Texas A&M)
July 09, 2017
Congratulations to Tianyu Jiang for acceptance of a manuscript, entitled "New bioluminescent coelenterazine derivatives with various C-6 substitutions", by Organic & Biomolecular Chemistry!
June 08, 2017
Lian He and Qian Zhang published a chapter, entitled "Optogenetic approaches to control calcium entry in non-excitable cells", in the book Calcium Entry Channels in Non-Excitable Cells by CRC Press.
June 7, 2017
Lian He and Ji Jing published a COVER STORY at Chemical Science, entitled "Optical Control of Membrane Tethering and
Interorganellar Communication at Nanoscales"!
May 26, 2017
Lian He and Ji Jing won the 2017 travel awards in recognition of their excellent research achievements!
May 8, 2017
The Texas A&M University System Board of Regents has officially approved Dr. Yubin Zhou's early promotion to the rank of Associate Professor with Tenure after four-and-half years' service at TAMU-IBT.
April 28, 2017
Ji Jing and Minjung Lee won the Outstanding Graduate Research Award at the 31th SCBA-TX annual meeting!
April 19, 2017
An article entitled "Discovery of the first environment-sensitive fluorescent probe for GPR120 (FFA4) imaging" was published online at ACS Medicinal Chemistry Letters! (collaboration with Dr. Minyong Li at SDU)
April 5, 2017
An article entitled "cybLuc: An Effective Aminoluciferin Derivative for Deep Bioluminescence Imaging" was published online at Analytical Chemistry! (collaboration with Dr. Minyong Li at SDU)
March 15, 2017
Yi Liang and Guolin Ma published a paper, entitled "Engineered split-TET2 enzyme for inducible epigenetic remodeling", at the Journal of the American Chemical Society !
- Highlighted in ACS Editors' Choice (based on the recommendations from over 400 editors of ACS' 40+ premier journals).
February 1, 2017
Guolin Ma, Yuepeng Ke and Lian He published an article by Current Molecular Medicine, entitled "Molecular determinants for STIM1 activation during store-operated Ca2+ entry"! Highlighted in Editor's Choice!
January 12, 2017
Congratulations to Guolin Ma as a co-author for a research article accepted by Nature Cell Biology, entitled "The LINK-A lncRNA interacts with PI(3,4,5)P3 to hyperactivate AKT and confer resistance to AKT inhibitors"!
ZHOU LAB | 2016 NEWS
ZHOU LAB | 2016 NEWS
November 21, 2016
Congratulations to Ji Jing for winning a Travel Award from the Graduate & Professional Student Council at Texas A&M University!
At the 2016 Institute of Biosciences and Technology (IBT) Trailblazers Luncheon honoring Dr. Arthur Laganowsky, recipient of an NIH Directors New Innovator Award, Dr. Yun (Nancy) Huang, recipient of CPRIT Emerging Investigator Award, and Dr. Yubin Zhou, American Cancer Society Research Scholar Award, pictured with Dr. Carrie Byington, Vice Chancellor for Health Services, Dean of the College of Medicine and Sr. VP for the Health Science Center at Texas A&M University. Congratulations to the trailblazers taking medicine from the field to the clinic! #BeFearless
September 14, 2016
Congratulations to Lian He and Peng Tan as co-authors for an article accepted by Molecular Cell, entitled "TRIM14 inhibits cGAS degradation mediated by selective autophagy
receptor p62 to promote innate immune response"!
September 12, 2016
Congratulations to Lian He and Guolin Ma as co-authors for a paper accepted by Pluger Arhiv - European Journal of Physiology, entitled "Molecular mechanisms underlying inhibition of STIM1-Orai1 mediated Ca2+ entry induced by 2-aminoethoxydiphenyl borate"!
January 28, 2016
A research article entitled "Discovery of the first environment-sensitive near-infrared (NIR) fluorogenic ligand for a1-adrenergic receptors imaging in vivo" was published at Journal of Medicinal Chemistry.
January 20, 2016
A research article entitled "SKF-96365 activates cytoprotective autophagy to delay apoptosis in colorectal cancer cells through inhibition of the calcium/CaMKIIy/AKT-mediated pathway" was published at Cancer Letters!
January 11, 2016
Congratulations to Guolin Ma as a co-author for a paper accepted by Nature Cell Biology, entitled "The LINK-A lncRNA Activates Normoxic HIF1α Signaling in Triple-negative Breast Cancer"!
January 5, 2016
A research article entitled "A novel environment-sensitive fluorescent probe for the human Ether-a-go-go-related gene potassium channel" by Zhenzhen Liu et al was published at Analytical Chemistry.
ZHOU LAB | 2015 NEWS
December 8, 2015
Congratulations to Lian He, Guolin Ma and Peng Tan for an article published by eLife, entitled "Near-infrared photoactivatable control of Ca2+ signaling and optogenetic immunomodulation"!
December 7, 2015
Congratulations to Ji Jing as a co-author for a paper published by PNAS, entitled "TMEM110 regulates the maintenance and remodelling of mammalian ER-plasma membrane junctions competent for STIM–ORAI signaling"!
November 16, 2015
Qian Zhang joined the Zhou Lab as a visiting scholar --- Welcome!!!
September 30, 2015
Congratulations to Ji Jing & Lian He for an article published at Nature Cell Biology, entitled "Proteomic mapping of ER-PM junctions identifies STIMATE as a regulator of Ca2+ influx"(doi: 10.1038/ncb3234).
Featured as "News and Views" by Nature Cell Biology: "STIMATE reveals a STIM1 transitional state"
September 12, 2015
A review entitled "SOCE and cancer: recent progress and new perspectives" was accepted by International Journal of Cancer.
July 22, 2015
An online protocol describing "Proteomic mapping of ER-PM junctions in living HEK293 cells" by Lian He et al. was available at Nature Protocol Exchange.
June 16, 2015
Congratulations to Dr. Guolin Ma & Lian He for the acceptance of a research article by Nature Communications, entitled "Inside-out calcium signaling prompted by STIM1 conformational switch".
Videos associated with this article is available at Youtube
May 20, 2015
Congratulations to Ji Jing for winning the 3rd Prize for outstanding performance and excellence in oral scientific presentation at the 29th SCBA-Texas Annual Symposium!
March 3, 2015
A research article entitled "Fluorogenic probe for the human Ether-a-go-go-related gene potassium channel imaging" by Zhenzhen Liu et al was published at Analytical Chemistry.
Zhenzhen Liu and Dr. Hongli Li joined the Zhou Lab as visiting scholars --- Welcome!!!
ZHOU LAB | 2014 NEWS
October 09, 2014
An article entitled "STIM1 triggers a gating rearrangement at the extracellular mouth of the ORAI1 channel." was published online by Nature Communications. 2014,5:5164. (PMID:25296861).
August 1, 2014
The Zhou Lab received an RO1 grant from National Institutes of Health to study the molecular controlling mechanisms of ER-PM junctions in mammalian cells.
July 31, 2014
IBT Imaging Workshop by the joint IBT-Baylor Center for Advanced Imaging
Featuring high-content imaing and analysis, 3D imaing, TIRF microscopy, mRNA FISH and spectral imaging with NIKON confocal setup.
Location: Rm 1119
12:00 am -1:00 pm, July 31, 2014
Free food and drinks provided
March 14, 2014
IBT Technology Forum:
CRISPR/CAS9 as a versatile platform for genome editing and engineering
Location: Rm 1119
12:00 am -1:00 pm, March 14, 2014
February 4, 2014
Welcome Can Li for joining the Zhou Lab as a rotation student!
ZHOU LAB | 2013 NEWS
November 21, 2013
IBT-BCM Center for Advanced Imaging Workshop
Location: Rm 1119
12:00 am -1:00 pm, December 20, 2013
November 9, 2013
Welcome Shin Hanna for joining the lab as a rotation student!
July 14, 2013
An article entitled "Initial activation of STIM1, the regulator of store-operated calcium entry" by Zhou Y et al. was published online (doi:10.1038/nsmb.2625) by Nature Structural & Molecular Biology. 2013,20:973-981.
Highlighted in NSMB "NEWS AND VIEWS"
June 3, 2013
A book chapter entitled "STIM-ORAI interactions that control the CRAC channel" by Gudlur A, Zhou Y and Hogan PG was published online by Current Topics in Membranes. [PMID: 23890110]
May 10, 2013
Congratulations to Lian He, M.S., for winning the poster award at the 2013 Annual IBT Research Symposium!
March 13, 2013
An article by Zhou Y et al. was published online and showcased as back cover of Metallomics issue 1, 2013 (see comments in Metallomics Blog). Calciomics: integrative studies on Ca2+ binding proteins and their interactomes in biological systems. [PMID: 23235533]
January 31, 2013
Nikon fluorescence microscope on-site training
Location: Suite 909
10:00 am -12:00 pm, January 31 Thursday 2013
January 9, 2013
A book chapter entitled "Probing Ca2+ binding capability of viral proteins with the EF-hand motif by grafting approach" for Methods in Molecular Biology by Zhou Y et al. was published online.